OTHER NAMES: Janimine, Tipramine, Tofranil, Tofranil-PM

Why is this drug prescribed?
Imipramine is used to treat bedwetting in children and unstable bladder problems in adults. It is also an antidepressant or mood elevator, used in the treatment of depression.

When should it be used?
Imipramine is taken one or more times a day. For bedwetting, it usually is taken once a day at bedtime. Follow the instructions on your prescription label carefully, and ask your doctor or pharmacist to explain any part that you do not understand. Imipramine must be taken regularly to be effective. Do not skip doses, even if you feel you do not need them. The drug must be taken regularly for two or more weeks before its full effect is felt.

How should it be used?
Imipramine comes in tablets or capsules. Your prescription label tells you how much to take at each dose. Ask us or your pharmacist any questions you have about refilling your prescription.

What special instructions should I follow while using this drug?
Imipramine can cause drowsiness, especially during the first few weeks you take it. Do not drive a car or operate dangerous machinery until you know how this drug affects you. Keep all appointments with us. Your dose may need to be adjusted occasionally. Do not stop taking Imipramine abruptly, especially if you have taken large doses for a long time. We will want to decrease your dose gradually.

What should I do if I forget to take a dose?
If you take more than one dose per day, take the missed dose as soon as you remember it and take any remaining doses for that day at the regularly scheduled times. If you remember a missed dose at the time you are scheduled to take the next one, omit the missed dose entirely. If you take Imipramine once a day and remember a missed dose within four hours of the time when you should have taken it, take it immediately. Otherwise, omit the missed dose entirely.

What side effects can this drug cause? What can I do about them?
Drowsiness, weakness, tiredness, anxiety (in children), excitement, insomnia Take this drug at bedtime if it causes drowsiness; take it in the morning if it causes insomnia. If you take this drug more than once a day, discuss with us whether it would be better to take it once a day.

  • Dry mouth
    Suck sugarless hard candies.
  • Constipation, blurred vision, difficulty urinating
    Contact your doctor if these effects persist or are severe.
  • Dizziness, lightheadedness, faintness when getting up from a sitting or lying position
    Get up slowly.
  • Persistent, fine tremor; shuffling walk; slow speech; difficulty swallowing; drooling; slow, jerky movements; jaw, neck, and back muscle spasms; inability to sit still; sore throat, fever, skin rash, and yellowing of skin or eyes; irregular heartbeat
    Contact us.

What other precautions should I follow while using this drug?
Before you take Imipramine, tell us if you are allergic to aspirin or tartrazine (a yellow dye in some processed foods and medications, including Imipramine) and what prescription and nonprescription drugs you are taking, especially MAO inhibitors (Isocarboxazid, Pargyline, Phenelzine, and Tranylcypromine); medication for high blood pressure, seizures, asthma, colds, or allergies; sedatives; tranquilizers; sleeping pills; anticoagulants ("blood thinners"); muscle relaxants; narcotics (pain medication); thyroid medication; Levodopa; antihistamines; and Methylphenidate.

Also tell us if you are pregnant or breast-feeding or if you have glaucoma, an enlarged prostate, difficulty urinating, a history of seizures, an overactive thyroid gland or a heart condition. If you become pregnant while taking this drug, promptly notify your doctor.

Before having surgery, tell the surgeon that you take Imipramine. Imipramine can make your skin more sensitive to sunlight than usual. Wear protective clothing and a sunscreen preparation. Alcohol can add to the drowsiness caused by this drug. Limit your consumption of alcoholic beverages. Do not allow anyone else to take this medication.

What storage conditions are necessary for this drug?
Keep this medication in the container it came in, tightly closed, and out of the reach of children. Store it at room temperature.